Superantigen as suspect

Functionally Suspect: Reconceptualizing "Race" as a Suspect Classification

Prime suspect.

Background: Human T-lymphotropic virus type-1 (HTLV-1) causes adult T-cell leukemia/ lymphoma and is linked to a number of lymphocyte-mediated disorders. HTLV-1 contains both regulatory and accessory genes in four pX open reading frames. pX ORF-II encodes two proteins, p13 and p30, whose roles are still being defined in the virus life cycle and in HTLV-1 virus-host cell interactions. Proviral c...

Glaucoma Suspect

Glaucoma suspect describes a person with one or more risk factors that may lead to glaucoma, but this individual does not have definite glaucomatous optic nerve damage or visual field defect. The number of individuals with eye findings that raise a suspicion of glaucoma, usually elevated intraocular pressure (IOP) or asymmetric optic disk morphology, far exceeds the number of people who have be...

Suspect cubic diamond "impact" proxy and a suspect lonsdaleite identification.

Rabies superantigen as a Vbeta T-dependent adjuvant

Recently we reported evidence that nucleocapsid (NC) of rabies virus is a Vbeta8-specific exogenous superantigen (SAg) in humans and a Vbeta6-specific SAg in BALB/c mice. NC was also found to stimulate rabies vaccination by enhancing the rabies neutralizing antibody response. In this study, we tested the hypothesis that the stimulating effect of NC and its SAg properties are linked. To do this,...